Our Science

Clinical trials

From Promising Science to Patient Care

We apply our science to discover and develop first-in-class or best-in-class medicines with the goal of creating transformational anti-cancer therapeutics. We conduct clinical trials to help confirm that our medicines offer genuine benefit, while balancing the risk of side effects. It’s part of our commitment to advance novel therapeutics and make a meaningful difference in the lives of people with cancer.

We’re committed to sharing information from completed clinical trials through public registries, scientific literature, and presentations. If you’d like additional information about one of our trials, please submit a request.

Brentuximab Vedotin

Study

Therapeutic Area(s)

Phase

Recruiting Status

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL Learn More

Diffuse Large B-cell Lymphoma

Phase 3

Recruiting

Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma Learn More

Hodgkin Lymphoma

Phase 2

Recruiting

A Study of Nivolumab Plus Brentuximab Vedotin in Patients Between 5 and 30 Years Old, With Hodgkin's Lymphoma (cHL), Relapsed or Refractory From First Line Treatment Learn More

Hodgkin Disease

Phase 2

Recruiting

Enfortumab Vedotin

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Study to Evaluate Enfortumab Vedotin in Subjects With Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors (EV-202) Learn More

Locally Advanced or Metastatic Malignant Solid Tumors

Phase 2

Recruiting

Enfortumab Vedotin and Pembrolizumab, With or Without Chemotherapy, vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer (EV-302) Learn More

Urothelial Cancer

Phase 3

Recruiting

Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303) Learn More

Urinary Bladder Cancer, Muscle-invasive

Phase 3

Recruiting

Ladiratuzumab Vedotin

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors Learn More

Small Cell Lung Cancer,
Non-small Cell Lung Cancer, Squamous,
Non-small Cell Lung Cancer, Non-squamous,
Head and Neck Squamous Cell Carcinoma,
Esophageal Squamous Cell Carcinoma,
Gastric Adenocarcinoma,
Gastroesophageal Junction Adenocarcinoma

Phase 2

Recruiting

Safety and Efficacy of SGN-LIV1A Plus Pembrolizumab for Patients With Locally-Advanced or Metastatic Triple-Negative Breast Cancer Learn More

Breast Neoplasms

Phase 1,
Phase 2

Recruiting

A Safety Study of SGN-LIV1A in Breast Cancer Patients Learn More

Breast Cancer

Phase 1

Recruiting

Tisotumab Vedotin

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Study of Weekly Tisotumab Vedotin for Patients With Platinum-Resistant Ovarian Cancer With Safety Run-in (innovaTV 208) Learn More

Ovarian Cancer,
Fallopian Tube Cancer,
Peritoneal Cancer

Phase 2

Recruiting

Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors Learn More

Colorectal Neoplasms,
Carcinoma, Non-Small-Cell Lung,
Exocrine Pancreatic Cancer,
Carcinoma, Squamous Cell of Head and Neck

Phase 2

Recruiting

Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other Cancer Agents in Subjects With Cervical Cancer Learn More

Cervical Cancer

Phase 1,
Phase 2

Recruiting

Tucatinib

Study

Therapeutic Area(s)

Phase

Recruiting Status

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy for HER2+ Gastrointestinal Cancers Learn More

Colorectal Carcinoma,
Gastric Adenocarcinoma,
Esophageal and GEJ Adenocarcinoma,
Cholangiocarcinoma,
Gallbladder Carcinoma

Phase 1

Recruiting

A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer Learn More

HER2-positive Breast Cancer

Phase 3

Recruiting

Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer Learn More

Metastatic Colorectal Adenocarcinoma

Phase 2

Recruiting

SEA-BCMA

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Safety Study of SEA-BCMA in Patients With Multiple Myeloma Learn More

Multiple Myeloma

Phase 1

Recruiting

SEA-CD40

Study

Therapeutic Area(s)

Phase

Recruiting Status

Safety Study of SEA-CD40 in Cancer Patients Learn More

Cancer,
Carcinoma,
Carcinoma, Non-Small-Cell Lung,
Carcinoma, Squamous Cell,
Hematologic Malignancies,
Hodgkin Disease,
Lymphoma,
Lymphoma, B-Cell,
Lymphoma, Follicular,
Lymphoma, Large B-Cell, Diffuse,
Melanoma,
Neoplasms,
Neoplasm Metastasis,
Neoplasms, Head and Neck,
Neoplasms, Squamous Cell,
Non-Small Cell Lung Cancer,
Non-Small Cell Lung Cancer Metastatic,
Non-small Cell Carcinoma,
Squamous Cell Cancer,
Squamous Cell Carcinoma,
Squamous Cell Carcinoma of the Head and Neck,
Squamous Cell Neoplasm,
Lymphoma, Non-Hodgkin,
Pancreatic Adenocarcinoma

Phase 1

Recruiting

SEA-CD70

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies Learn More

Myelodyspastic Syndrome,
Acute Myeloid Leukemia

Phase 1

Recruiting

SGN-TGT

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Safety Study of SGN-TGT (SEA-TGT) in Patients With Advanced Cancer Learn More

Non-small Cell Lung Cancer,
Gastric Carcinoma,
Classical Hodgkin Lymphoma,
Diffuse Large B-cell Lymphoma,
Peripheral T-cell Lymphoma

Phase 1

Recruiting

SGN-B6A

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Study of SGN-B6A in Advanced Solid Tumors Learn More

Non-small Cell Lung Cancer,
Head and Neck Squamous Cell Cancer,
Breast Cancer,
Esophageal Cancer,
Ovarian Cancer,
Cutaneous Squamous Cell Cancer,
Exocrine Pancreatic Adenocarcinoma,
Bladder Cancer,
Cervical Cancer,
Gastric Cancer

Phase 1

Recruiting

SGN-CD228A

Study

Therapeutic Area(s)

Phase

Recruiting Status

A Study of SGN-CD228A in Advanced Solid Tumors Learn More

Cutaneous Melanoma,
Pleural Mesothelioma,
Breast Cancer,
Non-small Cell Lung Cancer,
Colorectal Cancer,
Pancreatic Ductal Adenocarcinoma

Phase 1

Recruiting

Understanding clinical trials

Considering a clinical trial? Learn more about the possible benefits and risks, what to expect, and how to find out if you’re eligible.

Learn More

Request additional information

Request additional information about an investigational therapy.

Contact Medical Information