Dacetuzumab (SGN-40)We and Genentech are currently conducting clinical trials of dacetuzumab in the following indications. Details on each of these ongoing studies can be found on the linked pages of www.clinicaltrials.gov.
If you or your physician have any questions about these clinical trials, please e-mail Seattle Genetics at clinicaltrials@seagen.com. Product Candidate Details Dacetuzumab is a monoclonal antibody that targets CD40. CD40 is a cell surface antigen that is expressed on several tumor types, including multiple myeloma, non-Hodgkin lymphoma and solid tumors including bladder and renal cancer. About Diffuse Large B-Cell Lymphoma Non-Hodgkin lymphoma represents a diverse group of cancers that develop in the lymphatic system. When lymphocytes, or white blood cells, which are responsible for defending the body against infection, divide and multiply uncontrollably, malignant tumors can form. The American Cancer Society estimates that more than 66,000 people would be diagnosed with NHL in the United States in 2008 and approximately 19,000 will die from the disease. Diffuse large B-cell lymphoma is an aggressive subtype of NHL, representing approximately 70% of all newly diagnosed cases of aggressive disease. About Multiple Myeloma Myeloma is a cancer of plasma cells, a type of white blood cell found primarily in the bone marrow. In myeloma, a plasma cell becomes malignant and grows continuously, destroying normal bone tissue and crowding out normal blood cell production. Multiple myeloma is an incurable disease in which patients can experience symptoms that significantly impact their quality of life, including pain, anemia, fatigue, recurrent infection and kidney failure. The American Cancer Society estimates that nearly 20,000 new cases of multiple myeloma would be diagnosed in the United States during 2008. Additional Resources For information on non-Hodgkin lymphoma, visit the Leukemia and Lymphoma Society at www.leukemia-lymphoma.org. For information on multiple myeloma, visit the Multiple Myeloma Research Foundation at www.multiplemyeloma.org. For additional information about advanced carcinomas and relevant support groups please go to the American Cancer Society Web Site at www.cancer.org. |